diff --git a/Makefile b/Makefile
index 7a21d12..545e84a 100644
--- a/Makefile
+++ b/Makefile
@@ -690,15 +690,12 @@
 		$(eval $(var)=yes)))
 endif
 
-# Disable feature groups
-ifeq ($(CONFIG_ENABLE_LIBUSB0_PROGRAMMERS), no)
-override CONFIG_PICKIT2_SPI = no
-endif
 ifeq ($(CONFIG_ENABLE_LIBUSB1_PROGRAMMERS), no)
 override CONFIG_CH341A_SPI = no
 override CONFIG_DEDIPROG = no
 override CONFIG_DIGILENT_SPI = no
 override CONFIG_DEVELOPERBOX_SPI = no
+override CONFIG_PICKIT2_SPI = no
 endif
 ifeq ($(CONFIG_ENABLE_LIBPCI_PROGRAMMERS), no)
 override CONFIG_INTERNAL = no
@@ -863,7 +860,7 @@
 ifeq ($(CONFIG_PICKIT2_SPI), yes)
 FEATURE_CFLAGS += -D'CONFIG_PICKIT2_SPI=1'
 PROGRAMMER_OBJS += pickit2_spi.o
-NEED_LIBUSB0 += CONFIG_PICKIT2_SPI
+NEED_LIBUSB1 += CONFIG_PICKIT2_SPI
 endif
 
 ifneq ($(NEED_LIBFTDI), )
@@ -1034,11 +1031,6 @@
 
 endif
 
-ifneq ($(NEED_LIBUSB0), )
-CHECK_LIBUSB0 = yes
-FEATURE_CFLAGS += -D'NEED_LIBUSB0=1'
-USBLIBS := $(call debug_shell,[ -n "$(PKG_CONFIG_LIBDIR)" ] && export PKG_CONFIG_LIBDIR="$(PKG_CONFIG_LIBDIR)" ; $(PKG_CONFIG) --libs libusb || printf "%s" "-lusb")
-endif
 
 ifneq ($(NEED_LIBUSB1), )
 CHECK_LIBUSB1 = yes
@@ -1190,23 +1182,6 @@
 endef
 export PCI_GET_DEV_TEST
 
-define LIBUSB0_TEST
-#include "platform.h"
-#if IS_WINDOWS
-#include <lusb0_usb.h>
-#else
-#include <usb.h>
-#endif
-int main(int argc, char **argv)
-{
-	(void) argc;
-	(void) argv;
-	usb_init();
-	return 0;
-}
-endef
-export LIBUSB0_TEST
-
 define LIBUSB1_TEST
 #include <stddef.h>
 #include <libusb.h>
@@ -1272,28 +1247,6 @@
 		rm -f .test.c .test.o .test$(EXEC_SUFFIX); exit 1; }; }; } 2>>$(BUILD_DETAILS_FILE); echo $? >&3 ; } | tee -a $(BUILD_DETAILS_FILE) >&4; } 3>&1;} | { read rc ; exit ${rc}; } } 4>&1
 	@rm -f .test.c .test.o .test$(EXEC_SUFFIX)
 endif
-ifeq ($(CHECK_LIBUSB0), yes)
-	@printf "Checking for libusb-0.1/libusb-compat headers... " | tee -a $(BUILD_DETAILS_FILE)
-	@echo "$$LIBUSB0_TEST" > .test.c
-	@printf "\nexec: %s\n" "$(CC) -c $(CPPFLAGS) $(CFLAGS) .test.c -o .test.o" >>$(BUILD_DETAILS_FILE)
-	@{ { { { { $(CC) -c $(CPPFLAGS) $(CFLAGS) .test.c -o .test.o >&2 && \
-		echo "found." || { echo "not found."; echo;				\
-		echo "The following features require libusb-0.1/libusb-compat: $(NEED_LIBUSB0)."; \
-		echo "Please install libusb-0.1 headers or libusb-compat headers or disable all features"; \
-		echo "mentioned above by specifying make CONFIG_ENABLE_LIBUSB0_PROGRAMMERS=no"; \
-		echo "See README for more information."; echo;				\
-		rm -f .test.c .test.o; exit 1; }; } 2>>$(BUILD_DETAILS_FILE); echo $? >&3 ; } | tee -a $(BUILD_DETAILS_FILE) >&4; } 3>&1;} | { read rc ; exit ${rc}; } } 4>&1
-	@printf "Checking if libusb-0.1 is usable... " | tee -a $(BUILD_DETAILS_FILE)
-	@printf "\nexec: %s\n" "$(CC) $(LDFLAGS) .test.o -o .test$(EXEC_SUFFIX) $(LIBS) $(USBLIBS)" >>$(BUILD_DETAILS_FILE)
-	@{ { { { { $(CC) $(LDFLAGS) .test.o -o .test$(EXEC_SUFFIX) $(LIBS) $(USBLIBS) >&2 && \
-		echo "yes." || { echo "no.";						\
-		echo "The following features require libusb-0.1/libusb-compat: $(NEED_LIBUSB0)."; \
-		echo "Please install libusb-0.1 or libusb-compat or disable all features"; \
-		echo "mentioned above by specifying make CONFIG_ENABLE_LIBUSB0_PROGRAMMERS=no"; \
-		echo "See README for more information."; echo;				\
-		rm -f .test.c .test.o .test$(EXEC_SUFFIX); exit 1; }; } 2>>$(BUILD_DETAILS_FILE); echo $? >&3 ; } | tee -a $(BUILD_DETAILS_FILE) >&4; } 3>&1;} | { read rc ; exit ${rc}; } } 4>&1
-	@rm -f .test.c .test.o .test$(EXEC_SUFFIX)
-endif
 ifeq ($(CHECK_LIBUSB1), yes)
 	@printf "Checking for libusb-1.0 headers... " | tee -a $(BUILD_DETAILS_FILE)
 	@echo "$$LIBUSB1_TEST" > .test.c
diff --git a/meson.build b/meson.build
index 1923fdf..e1b6c16 100644
--- a/meson.build
+++ b/meson.build
@@ -67,7 +67,6 @@
 deps = []
 srcs = []
 
-need_libusb0 = false
 need_raw_access = false
 need_serial = false
 
@@ -91,6 +90,7 @@
   config_dediprog = false
   config_digilent_spi = false
   config_developerbox_spi = false
+  config_pickit2_spi = false
 endif
 
 # some programmers require libpci
@@ -242,7 +242,6 @@
 if config_pickit2_spi
   srcs += 'pickit2_spi.c'
   cargs += '-DCONFIG_PICKIT2_SPI=1'
-  need_libusb0 = true
 endif
 if config_pony_spi
   srcs += 'pony_spi.c'
@@ -293,11 +292,6 @@
   srcs += 'serial.c'
 endif
 
-# raw deprecated and old USB library
-if need_libusb0
-  deps += dependency('libusb')
-endif
-
 prefix = get_option('prefix')
 sbindir = join_paths(prefix, get_option('sbindir'))
 libdir = join_paths(prefix, get_option('libdir'))
diff --git a/meson_options.txt b/meson_options.txt
index 962866c..b7633d0 100644
--- a/meson_options.txt
+++ b/meson_options.txt
@@ -26,7 +26,7 @@
 option('config_nicnatsemi', type : 'boolean', value : false, description : 'National Semiconductor NICs')
 option('config_nicrealtek', type : 'boolean', value : true, description : 'Realtek NICs')
 option('config_ogp_spi', type : 'boolean', value : true, description : 'SPI on OGP cards')
-option('config_pickit2_spi', type : 'boolean', value : false, description : 'PICkit2 SPI')
+option('config_pickit2_spi', type : 'boolean', value : true, description : 'PICkit2 SPI')
 option('config_pony_spi', type : 'boolean', value : true, description : 'PonyProg2000 SPI')
 option('config_rayer_spi', type : 'boolean', value : true, description : 'RayeR SPIPGM')
 option('config_satamv', type : 'boolean', value : true, description : 'Marvell SATA controllers')
diff --git a/pickit2_spi.c b/pickit2_spi.c
index e13e721..6d9b28f 100644
--- a/pickit2_spi.c
+++ b/pickit2_spi.c
@@ -39,12 +39,7 @@
 #include <string.h>
 #include <limits.h>
 #include <errno.h>
-
-#if IS_WINDOWS
-#include <lusb0_usb.h>
-#else
-#include <usb.h>
-#endif
+#include <libusb.h>
 
 #include "flash.h"
 #include "chipdrivers.h"
@@ -57,7 +52,7 @@
 	{}
 };
 
-static usb_dev_handle *pickit2_handle;
+static libusb_device_handle *pickit2_handle;
 
 /* Default USB transaction timeout in ms */
 #define DFLT_TIMEOUT            10000
@@ -94,36 +89,18 @@
 #define SCR_VDD_OFF             0xFE
 #define SCR_VDD_ON              0xFF
 
-/* Might be useful for other USB devices as well. static for now.
- * device parameter allows user to specify one device of multiple installed */
-static struct usb_device *get_device_by_vid_pid(uint16_t vid, uint16_t pid, unsigned int device)
-{
-	struct usb_bus *bus;
-	struct usb_device *dev;
-
-	for (bus = usb_get_busses(); bus; bus = bus->next)
-		for (dev = bus->devices; dev; dev = dev->next)
-			if ((dev->descriptor.idVendor == vid) &&
-			    (dev->descriptor.idProduct == pid)) {
-				if (device == 0)
-					return dev;
-				device--;
-			}
-
-	return NULL;
-}
-
 static int pickit2_get_firmware_version(void)
 {
 	int ret;
 	uint8_t command[CMD_LENGTH] = {CMD_GET_VERSION, CMD_END_OF_BUFFER};
 
-	ret = usb_interrupt_write(pickit2_handle, ENDPOINT_OUT, (char *)command, CMD_LENGTH, DFLT_TIMEOUT);
-	ret = usb_interrupt_read(pickit2_handle, ENDPOINT_IN, (char *)command, CMD_LENGTH, DFLT_TIMEOUT);
+	int transferred;
+	ret = libusb_interrupt_transfer(pickit2_handle, ENDPOINT_OUT, command, CMD_LENGTH, &transferred, DFLT_TIMEOUT);
+	ret = libusb_interrupt_transfer(pickit2_handle, ENDPOINT_IN, command, CMD_LENGTH, &transferred, DFLT_TIMEOUT);
 
 	msg_pdbg("PICkit2 Firmware Version: %d.%d\n", (int)command[0], (int)command[1]);
-	if (ret != CMD_LENGTH) {
-		msg_perr("Command Get Firmware Version failed (%s)!\n", usb_strerror());
+	if (ret != 0) {
+		msg_perr("Command Get Firmware Version failed!\n");
 		return 1;
 	}
 
@@ -165,11 +142,11 @@
 		voltage_selector * 13,
 		CMD_END_OF_BUFFER
 	};
+	int transferred;
+	int ret = libusb_interrupt_transfer(pickit2_handle, ENDPOINT_OUT, command, CMD_LENGTH, &transferred, DFLT_TIMEOUT);
 
-	int ret = usb_interrupt_write(pickit2_handle, ENDPOINT_OUT, (char *)command, CMD_LENGTH, DFLT_TIMEOUT);
-
-	if (ret != CMD_LENGTH) {
-		msg_perr("Command Set Voltage failed (%s)!\n", usb_strerror());
+	if (ret != 0) {
+		msg_perr("Command Set Voltage failed!\n");
 		return 1;
 	}
 
@@ -201,10 +178,11 @@
 		CMD_END_OF_BUFFER
 	};
 
-	int ret = usb_interrupt_write(pickit2_handle, ENDPOINT_OUT, (char *)command, CMD_LENGTH, DFLT_TIMEOUT);
+	int transferred;
+	int ret = libusb_interrupt_transfer(pickit2_handle, ENDPOINT_OUT, command, CMD_LENGTH, &transferred, DFLT_TIMEOUT);
 
-	if (ret != CMD_LENGTH) {
-		msg_perr("Command Set SPI Speed failed (%s)!\n", usb_strerror());
+	if (ret != 0) {
+		msg_perr("Command Set SPI Speed failed!\n");
 		return 1;
 	}
 
@@ -270,18 +248,20 @@
 	buf[i++] = CMD_UPLOAD_DATA;
 	buf[i++] = CMD_END_OF_BUFFER;
 
-	int ret = usb_interrupt_write(pickit2_handle, ENDPOINT_OUT, (char *)buf, CMD_LENGTH, DFLT_TIMEOUT);
+	int transferred;
+	int ret = libusb_interrupt_transfer(pickit2_handle, ENDPOINT_OUT, buf, CMD_LENGTH, &transferred, DFLT_TIMEOUT);
 
-	if (ret != CMD_LENGTH) {
-		msg_perr("Send SPI failed, expected %i, got %i %s!\n", writecnt, ret, usb_strerror());
+	if (ret != 0) {
+		msg_perr("Send SPI failed!\n");
 		return 1;
 	}
 
 	if (readcnt) {
-		ret = usb_interrupt_read(pickit2_handle, ENDPOINT_IN, (char *)buf, CMD_LENGTH, DFLT_TIMEOUT);
+		int length = 0;
+		ret = libusb_interrupt_transfer(pickit2_handle, ENDPOINT_IN, buf, CMD_LENGTH, &length, DFLT_TIMEOUT);
 
-		if (ret != CMD_LENGTH) {
-			msg_perr("Receive SPI failed, expected %i, got %i %s!\n", readcnt, ret, usb_strerror());
+		if (length == 0 || ret != 0) {
+			msg_perr("Receive SPI failed\n");
 			return 1;
 		}
 
@@ -376,27 +356,24 @@
 		CMD_END_OF_BUFFER
 	};
 
-	int ret = usb_interrupt_write(pickit2_handle, ENDPOINT_OUT, (char *)command, CMD_LENGTH, DFLT_TIMEOUT);
+	int transferred;
+	int ret = libusb_interrupt_transfer(pickit2_handle, ENDPOINT_OUT, command, CMD_LENGTH, &transferred, DFLT_TIMEOUT);
 
-	if (ret != CMD_LENGTH) {
-		msg_perr("Command Shutdown failed (%s)!\n", usb_strerror());
+	if (ret != 0) {
+		msg_perr("Command Shutdown failed!\n");
 		ret = 1;
 	}
-	if (usb_release_interface(pickit2_handle, 0) != 0) {
+	if (libusb_release_interface(pickit2_handle, 0) != 0) {
 		msg_perr("Could not release USB interface!\n");
 		ret = 1;
 	}
-	if (usb_close(pickit2_handle) != 0) {
-		msg_perr("Could not close USB device!\n");
-		ret = 1;
-	}
+	libusb_close(pickit2_handle);
+	libusb_exit(NULL);
 	return ret;
 }
 
 int pickit2_spi_init(void)
 {
-	unsigned int usedevice = 0; // FIXME: Allow selecting one of multiple devices
-
 	uint8_t buf[CMD_LENGTH] = {
 		CMD_EXEC_SCRIPT,
 		10,			/* Script length */
@@ -442,32 +419,36 @@
 			return 1;
 	}
 
-	/* Here comes the USB stuff */
-	usb_init();
-	(void)usb_find_busses();
-	(void)usb_find_devices();
+	if (libusb_init(NULL) < 0) {
+		msg_perr("Couldn't initialize libusb!\n");
+		return -1;
+	}
+
+#if LIBUSB_API_VERSION < 0x01000106
+	libusb_set_debug(NULL, 3);
+#else
+	libusb_set_option(NULL, LIBUSB_OPTION_LOG_LEVEL, LIBUSB_LOG_LEVEL_INFO);
+#endif
+
 	const uint16_t vid = devs_pickit2_spi[0].vendor_id;
 	const uint16_t pid = devs_pickit2_spi[0].device_id;
-	struct usb_device *dev = get_device_by_vid_pid(vid, pid, usedevice);
-	if (dev == NULL) {
-		msg_perr("Could not find a PICkit2 on USB!\n");
+	pickit2_handle = libusb_open_device_with_vid_pid(NULL, vid, pid);
+	if (pickit2_handle == NULL) {
+		msg_perr("Could not open device PICkit2!\n");
+		libusb_exit(NULL);
 		return 1;
 	}
-	msg_pdbg("Found USB device (%04x:%04x).\n", dev->descriptor.idVendor, dev->descriptor.idProduct);
 
-	pickit2_handle = usb_open(dev);
-	int ret = usb_set_configuration(pickit2_handle, 1);
-	if (ret != 0) {
-		msg_perr("Could not set USB device configuration: %i %s\n", ret, usb_strerror());
-		if (usb_close(pickit2_handle) != 0)
-			msg_perr("Could not close USB device!\n");
+	if (libusb_set_configuration(pickit2_handle, 1) != 0) {
+		msg_perr("Could not set USB device configuration.\n");
+		libusb_close(pickit2_handle);
+		libusb_exit(NULL);
 		return 1;
 	}
-	ret = usb_claim_interface(pickit2_handle, 0);
-	if (ret != 0) {
-		msg_perr("Could not claim USB device interface %i: %i %s\n", 0, ret, usb_strerror());
-		if (usb_close(pickit2_handle) != 0)
-			msg_perr("Could not close USB device!\n");
+	if (libusb_claim_interface(pickit2_handle, 0) != 0) {
+		msg_perr("Could not claim USB device interface\n");
+		libusb_close(pickit2_handle);
+		libusb_exit(NULL);
 		return 1;
 	}
 
@@ -492,9 +473,9 @@
 
 	/* Perform basic setup.
 	 * Configure pin directions and logic levels, turn Vdd on, turn busy LED on and clear buffers. */
-	ret = usb_interrupt_write(pickit2_handle, ENDPOINT_OUT, (char *)buf, CMD_LENGTH, DFLT_TIMEOUT);
-	if (ret != CMD_LENGTH) {
-		msg_perr("Command Setup failed (%s)!\n", usb_strerror());
+	int transferred;
+	if (libusb_interrupt_transfer(pickit2_handle, ENDPOINT_OUT, buf, CMD_LENGTH, &transferred, DFLT_TIMEOUT) != 0) {
+		msg_perr("Command Setup failed!\n");
 		return 1;
 	}